Beauty and Skincare
Regeneration of the fresh young skin
with the same kind of effect as EGF
To promote regeneration of cells
by its own effect
EGF (Epidermal Growth Factor) is a kind of protein exists in human skin, which is discovered by Dr. Stanley Cohen, a Nobel-prize winner chemist. It is unveiled not only to regulate the cell function but also to promote their growth, so its effect as a beauty ingredient is remarked.
EGF secretion drastically declines after 20s as human age, and it declines to nearly half or one-third when we come to 40s. It leads to cell deterioration which causes skin troubles as drying, hardening ,wrinkles or moth patches.
It is clarified that proteoglycan has a same effect as EGF to promote regeneration of skin cells.
This is the original function that is not with collagen or hyaluronic acid, and moreover, it promotes production of collagen and hyaluronic acid themselves, which is the point to be greatly remarked as a material of aging care cosmetics.
To supplement function of EGF which is getting less as we age, as well as to activate and reinforce hyaluronic acid and collagen.
Both as a control tower and a star player of extracellular matrix, proteoglycan is a fundamental material to activate cells to keep themselves fresh and young.
Range of its application is not only for beauty, but it is also kept studied to be used for regenerative medicine to cover losses of tissues in the body.
■EGF decrease that accompanies the aging process
Researched by the Foundation of Growth Chemistry Association in 2006
■Test examples of beautiful skin regeneration by natural proteoglycan
52 years old woman (application)
Applied the PG beauty fluid with high purity proteoglycan (PG) 1% and methyl paraben 0.15% as a preservative two times a day every morning and night after face washing for continuous 12 weeks, and measured her skin 2 times, before and after application at the third party organization (Otemachi Park Clinic / Chiyoda-ku Tokyo).
44 years old woman (ingestion)
Drank the PG solution 100ml with high purity proteoglycan 100mg or equivalent two times a day before breakfast and before going to bed for continuous 12 weeks, and measured her skin 2 times, before and after application at the third party organization (Otemachi Park Clinic / Chiyoda-ku Tokyo).
High water-retention ability
beyond hyaluronic acid
Both application and ingestion are OK
Keep the moisture in skin cells
Suppleness, moisture and dew are foundations of beautiful skin.
Skins of babies are 80% made from water.
When we become adults, the water decreases to 60-70% and it keeps dipping as we age.
As moisture retention ingredients, hyaluronic acid and chondroitin sulfate are remarked for their high water retaining capacity.
But it is clarified that proteoglycan exceeds them 30% in the water retaining capacity.
One of the reasons is that hyaluronic acid is easy to be decomposed but proteoglycan is hard to be decomposed as well as hard to be dried by passage of time.
Also, hyaluronic acid can normally get a little effect in case of ingestion but proteoglycan can work both application and ingestion cases.
And the biggest difference from other ingredients as hyaluronic acid is that proteoglycan works as to promote genesis of hyaluronic acid and collagen inside skin.
More than as a simple ingredient that has amazing water-retaining capacity, proteoglycan reinforces other water retention ingredient, which we should call it a skin trouble savior from decline of water-retaining capacity or drying by aging.
■Comparison of moisture retaining capacities
Comparative test of moisture retaining capacities between natural proteoglycan, commercially available hyaluronic acid and chondroitin sulfate was done.
As a result, under circumstance of relative humidity (RH) 65%, hyaluronic acid was slightly higher in moisture retaining capacity. However, when the relative humidity was forced to be lowered to 35% on the eleventh day, both of the products released water and their weights dipped.
But there was a big difference in how their weight dips to prove that the moisture retaining capacities of natural proteoglycan is the highest.
So it was clearly shown that natural proteoglycan is the most effective for arid regions, dry seasons and dry skins.
■Comparison of water emission amount
Getting rid of dry skin/moth patches/wrinkles/loose skin
with its anti-inflammatory action
Dissolution of skin worries and troubles
to feel anti-aging
When we talk about skin-beautifying effect of natural proteoglycan, we cannot skip to mention about its anti-inflammatory action.
There might be someone who doubts its relevancy with skin-beautifying, but actually skin troubles as acne, dry skin or sunburn is a sort of inflammations.
Symptoms of aging as skin wrinkles, moth patches or loose skin are accelerated by cytokine TNF-α (Tumor Necrosis Factor-α) that causes inflammations.
TNF-α is also an aggravating factor for patients’ conditions as GVHD (Graft-Versus-Host-Disease) that are seen on diabetes, rheumatoid arthritis and marrow transplants.
Proteoglycan not only suppresses function of the cytokine but also activates function of anti-inflammatory cytokine (IL-10) that suppresses inflammations.
It has a dual effect to suppress inflammations.
So it is expected to be applied not only to skin troubles but also to prevention of inflammatory diseases and autoimmune disorder.
Also, sunburn is a skin inflammation that skin pigmentation is caused even after the inflammation stops, and moth patches come out to the skin as we age.
Proteoglycan works not only to suppress inflammations but also to improve pigmentation.
It is clarified that ingestion of proteoglycan lessened preeminent moth patches.
And cell assay also showed an effect to control melanin pigment generation which causes moth patches.
Like this, Proteoglycan not only prevents and restores skin damages but also refreshes and regenerates skin cells themselves back to be young. As an almighty ingredient for skin anti-aging that has both symptomatic treatment effect and complete cure effect, proteoglycan is expected to be applied to various products.
■A human study on application of proteoglycan essence
Target: Healthy 8 women from 40s to 60s
Applied the PG beauty fluid with high purity proteoglycan (PG) 1% and methyl paraben 0.15% as a preservative two times a day every morning and night after face washing for continuous 12 weeks, and measured their skin 2 times, before and after application at the third party organization (Otemachi Park Clinic / Chiyoda-ku Tokyo).
■A human study on ingestion of proteoglycan water solution
Target: Healthy 6 women from 40s to 60s
Drank the PG solution 100ml with high purity proteoglycan 100mg or equivalent two times a day before breakfast and before going to bed for continuous 12 weeks, and measured their skin 2 times, before and after application at the third party organization (Otemachi Park Clinic / Chiyoda-ku Tokyo).
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